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Slow-wave potential : ウィキペディア英語版 | Slow-wave potential
A slow wave potential is a rhythmic electrophysiological event in the gastrointestinal tract. The normal conduction of slow waves is one of the key regulators of gastrointestinal motility. Slow waves are generated and propagated by a class of pacemaker cells called the interstitial cells of Cajal, which also act as intermediates between nerves and smooth muscle cells. Slow waves generated in interstitial cells of Cajal spread to the surrounding smooth muscle cells and control motility. ==Description==
In physiology, the slow-wave threshold is the potential which must be reached before a slow wave can be propagated in smooth muscle. Slow waves cause no smooth muscle contraction.When the amplitude of slow waves in smooth muscle cells reaches a certain threshold—the slow-wave threshold—a particular membrane ion channel, L-type Ca2+ channels, are activated, resulting in calcium influx and initiation of motility. Slow waves are generated at unique intrinsic frequencies by the interstitial cells of Cajal, even within the same organ. Entrainment of these different intrinsic frequencies through electrical coupling allows these unique intrinsic frequencies to occur at a single frequency within the stomach and segments of the small intestine. Electron microscopic and dye coupling studies to date have confirmed gap junctions as the major coupling mechanisms between interstitial cells of Cajal 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Slow-wave potential」の詳細全文を読む
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